pharmacokinetic and pharmacodynamic processes

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Patient AO has a history of obesity and has recently gained 9pounds.   The patient has been diagnosedwith hypertension and hyperlipidemia.   The current medication list includes:
Atenolol 12.5 mg daily
Doxazosin 8 mg daily
Hydralazine 10 mg qid
Sertraline 25 mg daily
Simvastatin 80 mg daily
By Day 7 of Week 2
Write a 2- to 3-page paper that addresses the following:

Explain how the factor you selected might influence the pharmacokinetic and pharmacodynamic processes in the patient from the case study you were assigned above.
Describe how changes in the processes might impact the patient’s recommended drug therapy. Be specific and provide examples.
Explain how you might improve the patient’s drug therapy plan and explain why you would make these recommended improvements.
Remember to use the rubric as a checklist.